The Role of Epigenetics in Obesity-Driven Hyperlipidemia: Understanding Gene-Environment Interactions

Wambui Kibibi J.

School of Natural and Applied Sciences Kampala International University Uganda

ABSTRACT

Obesity-driven hyperlipidemia, characterized by elevated levels of lipids in the blood, represents a significant risk factor for cardiovascular diseases. While genetic predisposition plays a role, epigenetic modifications have emerged as key mediators of the complex interactions between genes and environmental factors, including diet, physical activity, and lifestyle. Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, modulate gene expression without altering the underlying DNA sequence, influencing lipid metabolism and fat accumulation. This review explores the role of epigenetics in obesity-driven hyperlipidemia, focusing on the mechanisms by which environmental factors shape gene expression and contribute to metabolic dysregulation. We highlight recent advances in understanding how epigenetic alterations can predispose individuals to lipid disorders and examine potential therapeutic interventions that target these modifications to mitigate hyperlipidemia in obese individuals. Additionally, we discuss the importance of personalized medicine approaches in the prevention and management of obesity-related lipid disorders, considering individual epigenetic profiles.

Keywords: Obesity-driven hyperlipidemia; Epigenetic modifications; Lipid metabolism; DNA methylation; Personalized medicine

CITE AS: Wambui Kibibi J. (2024). The Role of Epigenetics in Obesity-Driven Hyperlipidemia: Understanding Gene-Environment Interactions. IAA Journal of Scientific Research 11(3):27-31. https://doi.org/10.59298/IAAJSR/2024/113.2731